Annotation

نویسنده

  • W. Barry Wood
چکیده

One of the most interesting and least understood phenomena of bacterial immunity is organotropism. It concerns such questions as why pneumonia is commonly caused by pneumococci and virtually never by meningococci, when both are frequently carried in the upper respiratory tract; and why the meningococcus causes meningitis while its closest relative, the gonococcus, causes genitourinary disease. Perhaps the best documented example of organotropism relates to whooping cough. In a remarkable series of experiments, done with chick embryos, Buddingh' found that inoculation of 15-day old embryonated eggs with Bordetella pertussis resulted in eventual localization of the organism on the ciliated epithelium of the bronchial mucosa, whereas in 12to 13-day old embryos, in which ciliated cells had not yet appeared in the bronchi, no infection of the nonciliated epithelium occurred. Thus it appears that B. pertussis has a special predilection for the microenvironment of ciliated epithelial cells in the bronchial mucosa-a relation entirely in keeping with the pathological hallmark of human whooping cough: the localized proliferation of B. pertussis in the "muco-ciliary blanket" of the bronchi.' Organotropism relates not only to the affinity of specific organisms for different tissues in the same host but also for the same tissues in different hosts. When virulent bovine tubercle bacilli, for example, are injected intravenously (or even intrarenally) into guinea pigs, the kidneys remain free of progressive lesions, whereas the kidneys of rabbits treated in the same fashion become riddled with tubercles. It has been suggested that the greater susceptibility of the rabbit kidney may be due to its lack of an enzyme, spermine oxidase, which is present in the kidneys of guinea pigs and renders the tissue polyamines, spermine and spermidine, tuberculocidal.8 Whatever the mechanism, the difference is striking. Finally, the invasiveness of a single strain of bacteria may vary over a wide range in different parts of the same organ of the same host. It is this third facet of organotropism which was originally brought to light

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عنوان ژورنال:
  • The Yale Journal of Biology and Medicine

دوره 38  شماره 

صفحات  -

تاریخ انتشار 1966